Lisa Murkowski (R-Alaska), all voted to confirm Kavanaugh.
"It matters. It is needed and it is long overdue", she said, arguing that her support for Kavanaugh's confirmation does not negate the claims of sexual assault that have flooded forward in the wake of Christine Blasey Ford's testimony against the nominee.
"I do not believe that Brett Kavanaugh was her assailant", the Maine Republican told CNN's Dana Bash on "State of the Union" in an interview slated to air on Sunday.
"Shame on you!" protesters yelled from the Senate gallery.
"Her testimony was extremely fearless and I felt [it was] extremely credible and believable and it stands as such". Something happened to Dr. Ford. "And I know it for a fact because I spoke with her, she didn't stop". Kavanaugh has denied all allegations.
The only party dissenters were Republican Senator Lisa Murkowski, who had meant to vote no, and Democrat Joe Manchin, who voted yes.
Ahead of the vote, hundreds of people protested against Mr Kavanaugh's nomination at the US Capitol in Washington.
"The Democrats are willing to cause such destruction in the pursuit of power, just imagine the devastation they would cause if they ever obtained the power they so desperately want and crave", Trump said.
Speaking on the eve of Kavanaugh's confirmation vote this weekend, Nadler said there was evidence that Senate Republicans and the FBI had overseen a "whitewash" investigation of the allegations and the legitimacy of the Supreme Court was at stake.
Brett Kavanaugh will be sworn in as a justice to US Supreme Court on Saturday - hours after he was confirmed by the Senate, the court announced in a statement.
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Democrats are seen as having a solid chance to captured the House, fueled in part by women voters who are upset over Kavanaugh and dislike Trump.
The dispute over Kavanaugh has added fuel to campaigning for the midterm elections in November when Democrats will try to take control of Congress from the Republicans.
Collins' lengthy speech on the Senate floor dwelled as much on Kavanaugh's judicial record as on the sexual misconduct charges that have consumed his nomination. Joe Manchin of West Virginia was the only Democrat to vote in favor of confirmation. Kavanaugh appeared to have the support of every Republican but one, meaning his confirmation was all but assured.
In divergent and often bitter remarks before the Friday morning vote, senior senators delivered closing arguments that demonstrated how deeply the nomination has split the Senate.
McConnell, who stalled Barack Obama's nomination of Merrick Garland to the court in his final year in office and for whom the new conservative majority represents a defining achievement, predicted that Democratic tactics during confirmation battle would electrify Republican voters in November.
Ford's testimony to the Senate Judiciary Committee was broadcast live on television last Thursday and captured the attention of some 20 million people watching on broadcast and cable networks.
"Senators claiming to want a dignified debate should not repeat lies constructed by the Judiciary Committee that were cynically created to win support for Judge Kavanaugh".
Accusations against Kavanaugh energized the #MeToo social media movement that emerged after high-profile accusations of sexual assault and harassment by men in politics, the media and the entertainment industry. Trump mocked Ford on Tuesday during a political rally in MS, further angering Democrats and women campaigning for an end to sexual violence. That rare procedural maneuver left Kavanaugh with the same two-vote margin he'd have had if Murkowski and Daines had both voted.
While the documents have not been made public, Republicans said they did not back up sexual assault allegations by Ford, a psychology professor at Palo Alto University in California.
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