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Many breast cancer patients could avoid chemo

07 June 2018

The new study of almost 7,000 women found that use of the already available Oncotype DX gene test could pinpoint those women who needed chemotherapy, and those who did not.

The researchers performed a prospective trial between 2006 and 2010 involving 10,273 women with hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative, axillary node-negative breast cancer.

According to a research article "Epidemiology of breast cancer in Indian women" by Asia-Pacific Journal of Clinical Oncology, in India, breast cancer has been ranked number one cancer among Indian females.

New research suggests that more breast cancer sufferers may be able to avoid grueling chemotherapy treatment.

However, these are the results from a single patient and much larger trials will be needed to confirm the findings.

He said: This is a remarkable and extremely promising result, but we need to see this effect repeated in other patients before giving hope of a new immunotherapy for incurable metastatic breast cancer.

Proceeds from the U.S. Postal Service's breast cancer stamp helped fund this important study. Based on those findings, decisions are made on the need for post-surgical chemotherapy.

The TAILORx trial used the Oncotype DX test, now available on the NHS, which allows doctors to predict the likelihood of the breast cancer returning.

Thousands of women have been tested over the years using Oncotype DX to help determine the true effectiveness of chemo. Low scores mean women receive hormonal therapy only to keep cancer from spreading, while patients with a high score get hormonal therapy plus chemotherapy. It was the women in the intermediate stages of 11-25 who oncologists often had differing views when prescribing standards of care. "The trial was created to address this question, and provides a very definitive answer".

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In the nine years of the study, 93.9 percent of the patients only using hormone therapy survived breast cancer. All had received a mid-range Oncotype DX score.

For many patients, it's a hard choice to decide whether to go through chemotherapy.

Then, researchers studied the outcomes, including whether or not cancer recurred, and overall survival.

"We know all women over 50 score 0-25 can safely take endocrine therapy without chemo therapy".

Patients with a recurrence score of up to 10 out of 100 have been shown not to benefit from chemotherapy and only hormone treatment is required.

In clinical practice, he said, "application of this test would be expected to spare chemotherapy in about 70% of women and select chemotherapy in about 30%".

Judy, who lives in Florida had an aggressive form of advanced cancer where her major organs were getting involved and there was no scope for treatment with conventional methods such as a chemotherapy, surgery and radiation therapy.

A POTENTIAL cure for cancer may have been found in the USA after a woman suffering from an "incurable" breast cancer that had spread to some of her organs was cured of the killer illness.

Through genetic testing, they separated women more likely to have recurrent cancer, which could potentially spare thousands from the treatment. For those people, the side effects of chemotherapy could have been avoided, without making the treatment any less effective.

Many breast cancer patients could avoid chemo